Are U.S. tech billionaires reversing aging through stem cell injections?

 

 

This Issue's Introduction

How amazing are stem cells?

Brian Johnson's Legendary Journey with Stem Cells

The Application of Stem Cells in Clinical Research

Summary

Too long—don't feel like reading? Just check this out:

1. Brian Johnson, a 45-year-old American entrepreneur, spends $2 million annually to reverse his body’s aging process and regain a younger appearance. He has hired a team of doctors to closely monitor his physical functions. In addition to maintaining a strict diet and exercising daily, he also takes expensive medications and explores innovative treatments like stem-cell therapy, all in hopes of turning back the clock on his biological age.

2. The essence of aging lies in the fact that aged or dying body cells fail to be promptly renewed or replaced. However, supplementing with exogenous stem cells has opened up a new pathway—increasingly, research confirms that stem cells can play a crucial role in anti-aging and regenerative medicine. As clinical studies on stem cells continue to advance, Brian Johnson, the wealthy American tech entrepreneur, is likely just the beginning; in the future, "rejuvenation" is poised for even greater breakthroughs.

 

At 45, American entrepreneur Brian Johnson spends $2 million annually to reverse his body’s aging process and regain a younger appearance. He has hired a team of doctors to closely monitor his physical functions. In addition to maintaining a strict diet and exercising daily, he also takes expensive medications and explores cutting-edge therapies like stem-cell treatments, all in hopes of turning back the clock on his biological age.

 

One NEWS

How amazing are stem cells?

Stem cells are a type of multipotent cell with the ability to self-replicate; under certain conditions, they can differentiate into various specialized cell types, holding the potential to develop into blood, brain, bone, and all other organs in the human body.

In 2007, British scientist Anastasia wrote in the journal Nature, stating: "Adult stem cells are essential for the human body's self-repair and tissue regeneration, and the decline of adult stem cells is a major cause of human aging."

Stem cells sneak into your body and transform into any type of cell you need. They can replace old, worn-out cells, breathing new life into your body—just like swapping out old parts in a malfunctioning machine. And it’s not just a superficial fix; these cells can reach deep into every corner of your body, rejuvenating even the most exhausted tissues.

Moreover, these stem cells also have a secret weapon—exosomes, tiny packages packed with proteins and mysterious non-coding RNAs. They act like messengers for your cells, helping to repair and rejuvenate your body.

Now, let’s talk about skin. Stem cells can truly shine here—they have the remarkable ability to help your skin look younger and healthier. In fact, one study even found that applying stem cells along with a magical vitamin B3 derivative called niacinamide after laser treatment can work like a miracle, rejuvenating your skin while significantly reducing wrinkles and skin damage.

So, how do stem cells locate the damaged tissues that need them? It’s as if they’re equipped with a built-in GPS system, capable of detecting the body’s distress signals. They navigate through blood vessels, moving silently and stealthily—almost like ninjas—until they reach the injured area. Once there, they release growth factors and cytokines, which act like cellular superglue and bandages, helping to reduce inflammation and repair the damaged tissue. At the same time, they collaborate with the surrounding tissues, rallying reserve cells that have the ability to divide, working together to carry out the healing process. It’s truly a meticulously orchestrated rescue operation at the cellular level!

 

Section 2 NEWS

Brian Johnson's legendary journey with stem cells,

Johnson has been passionate about science since childhood, particularly admiring those who push the boundaries of human potential and strive to expand the frontiers of science. Later, he became the CEO of a technology company, started a family, and now has three children.

“My daily life consists of taking care of my child and working all day long. Every night, I try hard to fall asleep, but I just can’t seem to get any rest. In this state, it’s incredibly difficult to manage my diet—I’ve gained 45 pounds—and for over a decade, I’ve been battling depression, even contemplating suicide at one point.”

"Despite trying numerous solutions, nothing seemed to work," Johnson recalled. Johnson’s binge-eating and self-harm tendencies were most intense after 7 p.m. every night. He referred to himself during this time as the "nighttime version of Johnson" and decided to completely "fire" that part of himself, leaving only the "daytime version of Johnson" to lead a healthier, more fulfilling life—ideally even regaining the vitality he once had in his younger years.

According to the latest June 24 issue of the bestselling U.S. publication *Today's Business*, Johnson traveled to a luxury resort in the Bahamas to undergo a specialized treatment. This procedure involved injecting 300 million stem cells directly into six major joints throughout his body. The stem cells were harvested from the bone marrow of young individuals in Sweden by a company called Cell Collars Clinical, with the aim of creating "superhero-like joints" for Johnson—enhancing athletic performance, alleviating pain, and even potentially extending his lifespan.

(The Johnson family: three generations—grandparents, parents, and grandchildren)

Johnson’s father also underwent whole-body treatment, receiving a direct intravenous injection of 100 million stem cells, aimed at revitalizing his entire body. In the Bahamas, Johnson received stem cell injections over two days, with 150 million cells administered on each day. On the first day, the injections were delivered to both knees and the right hip, while the second day focused primarily on the left hip and both shoulders.

“The cells just arrived. The sooner we inject them into my body, the better,” Johnson said. The entire process is extremely time-sensitive—there’s only 28 minutes to get them injected into the targeted areas of my body.

Johnson did feel somewhat unwell, describing it as "like a car accident." But most of the time, he remained optimistic, viewing the pain as an inevitable part of his recovery process.

Johnson's three pieces of advice for ordinary people:

First, stop self-harming behaviors, including binge eating, consuming junk food, excessive alcohol consumption, and smoking.

Second, treat sleep as the most important thing in your life.

Third, eat more vegetables, fruits, and nuts.

“The next stage will be even more challenging—and equally thrilling—marking the true reversal of aging.” Team leader and physician Oliver Zolman has set an ambitious goal: by 2030, he aims to reverse the biological age of all 78 of Johnson’s organs by 25%. “I’ve already shared every detail and methodology freely online. It’s time for humanity to rethink our world and harness science to transform ourselves. We have the incredible opportunity to evolve into a better species, and I truly hope everyone can ‘win’ in this journey.”

Video: I Inject 300 Million Stem Cells to Create a Super Joint

 

Three NEWS

The Application of Stem Cells in Clinical Research

In 2018, the stem-cell project aimed at treating age-related frailty received an Innovative Research Grant from the U.S. National Institutes of Health (NIH). The Phase II clinical trial results for this therapy have now been published in the international journal *The Journals of Gerontology*. A total of 36 elderly patients with frailty syndrome—average age 76—participated in a randomized, double-blind, placebo-controlled clinical trial. After receiving intravenous infusions of allogeneic mesenchymal stem cells, many participants showed significant improvements in key symptoms characteristic of frailty, with no adverse reactions reported.

Injecting stem cells into damaged areas, such as the hips and knees, can promote tissue repair in those regions. Take osteoarthritis as an example. As people age, the production of cartilage cells declines, while the rate of cartilage breakdown outpaces its regeneration, leading to the gradual degeneration of joints and bones—and ultimately, the onset of osteoarthritis.

A Phase I clinical trial evaluated the intra-articular administration of two doses of mesenchymal stem cells, spaced one month apart, in 13 patients with knee osteoarthritis stages II and III. The patients were then followed up for two years to assess both the therapeutic efficacy and safety of the treatment. The results demonstrated that intra-articular injection of mesenchymal stem cells is safe for treating knee osteoarthritis, significantly improving both the Koos scores and knee cartilage thickness, thereby confirming the potential of stem cell therapy in alleviating osteoarthritis symptoms.

Overall, an increasing number of clinical studies have incorporated stem cells, and the targeted indications now extend beyond age-related diseases to include numerous other systemic conditions.

 

 

Four NEWS

Summary

Stem cells have shown tremendous potential in various fields, including aging research. However, further advancements in optimizing stem cell administration methods and standardizing preparation protocols still require larger-scale studies with more comprehensive data. This will ultimately pave the way for the clinical development of stem cell therapies in areas such as anti-aging.

In short, the essence of aging lies in the failure of aged or dying body cells to be promptly renewed or replaced. However, supplementing with exogenous stem cells has opened up a new avenue, and an increasing number of studies confirm that stem cells can play a critically important role in anti-aging and regenerative medicine. As clinical research on stem cells continues to advance, we believe that Brian Johnson, the American tech billionaire, is merely at the starting point—marking the beginning of what could lead to even greater breakthroughs in "rejuvenation" in the future.